By Margaret T. T. Wong-Riley Ph.D., Feng Nie, Robert F. Hevner, Suyan Liu (auth.), F. Gonzalez-Lima (eds.)
This e-book relies on a global symposium titled "Cytochrome oxidase in power metabolism and Alzheimer's disease," held as a satellite tv for pc to the twenty seventh assembly of the Society for Neuroscience, New Orleans, 1997. The symposium was once devoted in honor of Dr. Margaret T. T. Wong-Riley simply because, in our opinion, the cytochrome oxidase histo chemical procedure brought by means of Dr. Wong-Riley in 1979 was once the main major holiday via to map power metabolism within the whole mind because the 2-deoxyglucose procedure brought by means of Dr. Louis Sokoloff and co-workers in 1977. either one of those metabolic map ping strategies have made enormous contributions to mind examine by means of permitting an indispensable view of mind task. they've got additionally constructed into a number of really expert tech niques, together with purposes to the human mind. this sort of new purposes, that's defined intimately during this publication, is the quantitative cytochrome oxidase cytochemical process used to review Alzheimer's illness. the target of this booklet is to explain the function of cytochrome oxidase in neuronal metabolism and Alzheimer's disorder. even if genetic or environmental, the pathogenesis of Alzheimer's sickness comprises a cascade of a number of intracellular occasions, finally re sulting in failure of oxidative strength metabolism. may perhaps impairment of cytochrome oxi dase in power metabolism begin the degenerative approach? Cytochrome oxidase functionality and disorder are mentioned in courting to neuronal strength metabolism, neurodegen eration, and Alzheimer's ailment. The ebook is made from 10 chapters, divided into 3 significant parts.
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Additional info for Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease
And supragranular puffs (arrowheads) are in exact alignment. (C) A section cut from a normal cat lateral geniculate nucleus and reacted for CO histochemistry followed by CO immunogold silver staining. Note that the intensity of histochemical reaction closely matches the density of immunogold silver particles for darkly-reactive (D), moderately-reactive (M) and lightly-reactive (L) neurons. (A and B, modified from Hevner and Wong-Riley. , 1989). VI C 22 M. T. T. Wong-Riley etal. To investigate this issue further, we injected macaque monkeys monocularly with TTX for 3--4 weeks and examined their visual system by both CO histochemistry and CO immunohistochemistry.
1995). 5 mm; for C: I mm. , "I 26 M. T. T. Wong-Riley et al. chondrial respiration (Erecinska and Silver, 1989), and are severely affected by disruption of the oxidative pathway, as occurs in the mitochondrial genetic diseases (Harding, 1991). Proper mitochondrial functioning is thus of crucial importance to neurons. However, nuclear-mitochondrial coordination is complicated in neurons because most mitochondria reside far from the cell body, in axons and dendrites. In neurons, the nucleus must interact with mitochondria in distinct axonal and dendritic processes that are often thousands of microns or more away.
12D). Thus, the adjustment of CO levels is in response to altered neuronal activity. , 1989a; Wong-Riley, 1989, 1994) (Fig. 12E). These findings underscore the critical role of neuronal activity in regulating cytochrome oxidase levels in the brain. 2. Metabolical(v Most Active Neurons Are Most Vulnerable to Functional Deprivation. Do all mature neurons respond alike to the same functional insult? , 1989a). Neurons that were moderately reactive for cytochrome oxidase before the treatment exhibited a reduction of their enzyme activity, but they retained their normal mean size.